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KMID : 0377519930180010029
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Chung-Ang Journal of Medicine
1993 Volume.18 No. 1 p.29 ~ p.42
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Ultrastructural Study on the Changes of the Coronary Arterioles and the Effect of High Cholesterol Diet in the Spontaneously Hypertensive Rats
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김용기
류왕성/유언호/송계용/조성희
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Abstract
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Vascular lesions develop during the course of hypertension and are the major cause of morbidity and mortality from this disease. Some of these are protective in nature and are associated with a remodeling of the artery to better withstand the
increase
in wall tension resulting from the elevated intravascular pressure. Other responses to vascular injury caused by hypertension, however, can predispose the artery to further adverse consequences.
The spontaneously hypertensive rat (SHR) is generally held to be a reliable model and experimental counterpart for the essential hypertension in man. The present study was undertaken to evaluate the changes of coronary arterioles in SHP which had
taken
25 cholesterol diet and normal diet for 8 months.
The blood pressure of SHR rised gradually from the 5th week afer birth and reached nearly 190 mmHg at the 15th week. Raised blood cholesterol levels were observed in the rats fed high cholesterol diet. The mean percent lumen of the coronary
arterioles
was significantly reduced in SHR compared with that inWistar rats. The mean ratio of HDL cholesterol to total cholesterol concentrations was 63% in Wistarrats, 56% SHR fed normal diet and 45% in SHR fed 2% cholesterol diet.
Vascular pathology involved both intima and media in SHR and medial thickening was associated with decreased luminal diameters. There was marked proliferation of smooth muscle cells. The endothelial cells were larger and cytoplasm was rich in
organelles
and pinocytotic vesicles. The internal elastic lamina was very wide and irregular. The smooth muscle cells were more increased in the number and separated by more abundant connective tissue matrix in SHR fed high cholesterol diet.
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KEYWORD
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